Immunomorphological characterization and effects of 12-(S)-HETE on a dynamic intracellular pool of the αIIbβ3-integrin in melanoma cells
نویسندگان
چکیده
J. Tímár1, R. Bazaz2, V. Kimler3, M. Haddad3, D. G. Tang2, D. Robertson4, J. Tovari1, J. D. Taylor3 and K. V. Honn2,5,* 11st Institute of Pathology and Experimental Cancer Research, The Semmelweis Medical University, Budapest, Hungary Departments of 2Radiation Oncology, Chemistry and Pathology, and 3Biological Sciences, Wayne State University, Detroit MI 48202, USA 4Institute of Cancer Research, Royal Cancer Hospital, Haddow Labs, EM Unit, Belmont, Sutton, Surrey, UK 5Division of Cancer Biology, Gershenson Radiation Oncology Center, Harper Hospital, Detroit, MI 48201, USA
منابع مشابه
Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.
A M(r) 55,000 tumor cell-secreted cytokine has been described which influenced the migration of the producing cells and was called autocrine motility factor (AMF). Activation of the cell surface receptor for AMF (gp78) was shown to stimulate production of a 12-lipoxygenase metabolite of arachidonic acid, 12-(S)-hydroxyeicosatetraenoic acid [12-(S)-HETE], in highly metastatic murine melanoma cel...
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The present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of Phlomis kurdica. The antioxidant and anti-tyrosinase activity of MeOH extract from P. kurdica (MPk) were examined by DPPH radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. Furthermore, the effect of MPk on the melanin content, cellular tyrosinase ...
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